The prime contract is the top-level agreement between the owner and the general contractor — it sets the contract sum, the scope, the schedule, and the terms the whole job hangs off of. Everything the GC buys out downstream (the commitments) has to add up to deliver the prime contract's scope within its price.
Prime contract change orders (PCCOs) adjust the owner-GC agreement when scope changes, while commitment change orders (CCOs) adjust the subcontracts below it. Keeping the two sides reconciled — what the owner has approved versus what you've committed to subs — is central to protecting margin.